The Evolving Role of Ion Channels in Shaping Successful Drug Discovery - Live Webinar For more information, or to register for this event, visit The Evolving Role of Ion Channels in Shaping Successful Drug Discovery. Join Dr Michael Morton, Director and Co-founder of ApconiX in a live webinar on [...]
Dr Michael Morton is Attending Safety Pharmacology Society Dr Michael Morton will be attending the annual Safety Pharmacology Society Meeting being held virtually this year between 14th and 17th of September. Mike will be presenting Poster 030: Electrophysiological analysis of Seroquel’s activity in sodium ion channels, CiPA ion channels [...]
ApconiX Welcomes Dr Selvan Bavan ApconiX welcomes Dr Selvan Bavan, who joins us to carry out ion channel research using manual patch-clamp while learning more about using automated patch-clamp by working with Dr Michael Morton and Dr Karen Jones. Selvan commented, “Conventional manual patch-clamp is regarded as a ‘gold [...]
Cardiac Safety in Drug Development: CiPA In the second of a three-part series looking at cardiac safety testing in early drug discovery, Dr Michael Morton of ApconiX considers the CiPA initiative and how its integrated approach sits alongside existing strategies. What is the CiPA initiative and what does it [...]
ApconiX Welcomes Charlotte North ApconiX welcomes Charlotte North to the team. Charlotte graduated from Sheffield University in July with a degree in Biomedical Sciences and is working in the ApconiX Ion Channel Laboratory as an industry placement student this month. Charlotte has been spending her time, since graduating, exploring [...]
My Brush with Greatness It is wonderful to see the original publication of patch-clamp methodology included in Nature’s 10 extraordinary papers (published 22 October 2019). The ground-breaking work of Neher and Sakmann sits alongside the discovery of the structure of DNA, cell reprogramming and birth of nanomaterials. At this [...]
An Ascorbate-Induced Increase in Sodium Current The Challenge It is not uncommon for our clients to synthesise compounds for testing in in vitro assays that are largely insoluble, and sometimes this requires consideration of novel vehicles. Recently, when provided with a DMSO-insoluble compound, we explored using the aqueous solvent, [...]
Dr Kimberly Rockley's First Six Months at ApconiX Kimberly Rockley completed her PhD in the Division of Pharmacy at Durham University before joining us at ApconiX in June last year. Here she reflects on her first 6 months with the company. “Having gained a background in cancer biology, toxicology [...]
Dr Michael Morton Attends Genedata Biopharma Open Forum Dr Michael Morton is attending “Accelerating Biopharma R&D with Innovative Biopharma Data Management and Analysis” at the Swiss Embassy in London today. The event was organised by Genedata. Speakers include Dr Peter Whitfield, Senior Scientific Data Analyst at GSK, Chris Wilson, [...]
ApconiX Is Presenting a Poster at ELRIG 2019 ApconiX is delighted to be presenting a poster at ELRIG 2019 titled “Sodium channel selectivity of two anti-epileptic drugs.” The poster includes research started by our placement student Priscilla Dumenu. Dr Michael Morton, Dr Richard Knight, Dr Kimberly Rockley, Phumzile Sikakana [...]
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